The Root cause of Depression in the Bible

The root cause of depression in the Bible, science, and what the doctors say


  • Depression is a spiritual battle.
  • Depression is linked with sinful nature.
  • Satan wants us depressed.
  • Unforgiveness leads to depression and anxiety.

The link between sickness and demonic influence

Insanity, sickness, or physical disability were associated with sin. However, it’s not always the case (John 9:3). Luke 6:18 said those who came to hear Jesus were healed of their diseases; those “troubled” (mentally afflicted) by unclean spirits were cured.

Talk therapy helps, but the root cause remains

In the Bible, we are told to share each other’s burdens, seek wisdom from elders, and bear each other’s burdens. It’s similar to what happens in talk therapy, but without God. However, psychotherapy is a temporary remedy unless the cause is rooted out.


1. Depression is a spiritual battle in the mind

Victor Frankl specialized in neurology and psychiatry. He focused on depression and suicide. From 1925 to 1945, he developed Logotherapy. It believes that life’s purpose and meaning enable us to survive even with insurmountable challenges.

Frankl shows us that the root cause of depression is a spiritual battle in the mind. Satan takes advantage of our sinful weakness by suggesting the following lies.

  • Life has no meaning.
  • Life is hopeless; there is no solution.
  • I have no purpose in life.

His theory was put to the test during WW2. Like Job, he lost all his family possession and suffered at Auschwitz. Despite his unbearable situation, he chose to survive, knowing that “suffering had a purpose.” He believed external forces couldn’t break the “spiritual self.”

Revelation 12:9
And the great dragon was thrown down, that ancient serpent, the devil and Satan, the deceiver of the whole world—he was thrown down to the earth, and his angels were thrown down with him.

Case and point: Mark Goodnight on the root cause of depression

Mark Goodnight wanted to kill himself at age five and again at 15. Diagnosed with level-5 neuroticism, he suffered from anxiety and anhedonia.

He saw a dozen psychiatrists and took medication for a time. Mark read self-help books to soothe depression and even did illegal drugs—but none helped.

Things began to change when he started reading the Bible. When he became a Christian, someone laid hands and prayed for healing in Jesus’ name. Suddenly, the blackness that consumed his life for the last twenty-five years was gone instantly.

Case and point: Emily Millora Juson on avoiding depressive thoughts

Emily has cancer, and there were signs of spreading. Chemo helped, but the cancer returned at least three times. The struggle was real with physical pain and uncertainty, but deep depression was kept at bay.

She depended on God’s promises and saw plentiful miracles along the way. Each day passed into weeks and weeks into years. God sustains Emily to this day—devoid of chronic anxiety.

She memorized Bible verses and frequently listened to Christian music. Her mind was constantly filled with scriptures, praises, and thankfulness—Satan had nothing on her.


“It’s been 25 years since then, and I have no issue,” Mark said in a video below. True healing happens with Jesus. (1 Peter 2:24)

When doctors or faith did not seem to help

In 2018, Andrew Stoecklein, a young and vibrant megachurch Pastor, preached about depression, then killed himself. In 2019, Jarrid Wilson, church leader, and mental health advocate, committed suicide.

Likewise, Matthew, son of Rick Warren, killed himself. Jeff Morris, son of Charles, host of ‘Haven Today,’ died from a drug overdose.

Indeed, these men are not faithless, but they lost the battle—despite prayers, therapy, and medication. We do not have all the answers, but one thing is sure, Jesus wants to give us life to the fullest!

Divine affliction

There’s also “divine discipline” or affliction that causes brokenness and leads to repentance and salvation. Because God is sovereign—Holy and loving, He allows, if not causes, discomfort when we’re stubborn. He does it out of faithfulness to the elect.

Psalm 119:75
“I know, LORD, that your laws are righteous & that in faithfulness You afflicted me.”


2. Giving in to sinful nature leads to depression

When we engage in immorality, watch porn, or do illegal drugs, the pattern of sinful habits allows a satanic foothold. It creates a doorway for demons to attack the mind.

The person suffers guilt and condemnation that can lead to depression. Therefore, the root cause of depression is when we embrace our sinful nature by living in sin.

Apostle Paul had anxiety and struggled with his sinful nature, but he was always victorious in Christ. (2 Corinthians 11)

Romans 7:18-20
“For I do not do the good I want to do, but the evil I do not want to do—this I keep on doing…it is a sin living in me that does it.”


Case and point: Woman with schizophrenia whose root cause was the love of money

A woman was on and off at a mental hospital for schizophrenia and manic depression for a decade. After knowing Jesus, the episodes stopped. Without church fellowship, she returned to Buddhism years after.

She also became busy making money, and like a child of the world, she mocked God and declared herself an atheist who would instead worship the Chinese Buddha. Soon, her mental problem returned. Mental pills and injections helped, but they also turned her into a different person, controlled by the drugs.

Case and point: Daughter raised in a Christian home but chose to live in sin

Loving Christian parents brought up Carol (not her real name). Although it would cost a lot, her parents placed her in a reputable Christian high school in Wheaton. Many American public schools discourage Christian activities yet welcome Satan as an “after-school club.”

Carol’s disobedience caused her depression to spiral downward—despite efforts, prayers, and counseling. She had inappropriate relationships and harmful influences. Carol died of a heroin overdose.

Sinful habits allows satanic foothold.


3. Unforgiveness can lead to depression

A study led by Italy’s Department of Education in 2019 showed unforgiveness was related to hedonic balance (HB) and depression. In contrast, forgiveness is effective in regulating and reducing depression. 

Dysfunctional or aggressive behaviors triggered by anger, severing ties with friends, or ruminating about others can lead to depressive thoughts, loneliness, and guilt that leads to anxiety. [Deffenbacher et al., 1996]

  • God commands us to forgive because unforgiveness cause bitterness. (Ephesians 4:31-32)
  • It imprisons our minds and prevents us from experiencing true joy. (Psalm 32:1-2)
  • Unforgiveness is the root of bitterness and causes trouble. (Hebrews 12:14:15)
  • Forgiveness brings us peace of mind. (Colossians 3:12-15)

Colossians 3:12-15
“… If you have something against someone, forgive him. That is the way the Lord forgave you. And to all these things, you must add love… Let the peace of Christ have power over your hearts…”

Forgiveness brings us peace of mind.


4. Satan wants to corrupt our mind

In the USA and worldwide, depression tripled during the 2020 pandemic lockdown. It continues to get worse, affecting 1 in every 3 American adults.

A study revealed low income, being unmarried, and other stressors such as idleness were the leading causes. No wonder the enemy wants us to be alone, be lazy, and without a structure in life so he can influence the mind, all by himself.

With an empty mind filled with worldly thoughts, we allow Satan, the “god of this world,” to influence and corrupt our minds (2 Corinthians 4:4). The first thing he tells us is that “there is no hope.”

The frequent lie of the enemy: “There is no hope”

God may allow Satan to break our body, but those who hope in Jesus have hope and do not lose heart (2 Corinthians 4:16-18). On the other hand, Satan tells us “there is no hope,” and death is the only escape.

  • 1 Timothy 6:5 – Depraved mind
  • 2 Corinthians 3:14 – Dull mind
  • 2 Corinthians 4:4 – Blinded mind
  • 2 Kings 6:11 – Troubled mind
  • 2 Timothy 3:8 – Corrupt mind
  • Isaiah 61:3 – Spirit of “no hope”
  • Romans 8:7 – Sinful mind

CORRELATION OF FAITH & DEPRESSION: About 61% recover from depression much faster if they have a religious or spiritual affiliation. A higher percentage (75%) is found in suicide. However, very few studies show faith and prayer “cures” depressed people. [NCBI]


Repentance and the renewing of our mind can extinguish the root cause of depression, even in difficult physical circumstances

Unbelief is a sinful mental activity. When we choose to ignore or refuse Jesus as our only hope, we become faithless, causing us to be even more depressed. The reason repentance (change of mind) is a requirement for salvation.

Although physical pain or trauma may remain, pursuing the mind of Christ extinguishes the lies of Satan. We can learn a lot from the following testimonies:


Pursuing the mind of Christ extinguishes the lies of Satan.


5. God’s children are Satan’s trophy

God’s children are Satan’s trophies, but he can only harm us if God allows him. However, unbelievers are easy prey. He wants to devour God’s children (1 Peter 5:8); so they can fall in sin and fail in misery.

Doing so derides our Creator, who wants us to persevere and find joy through faith—despite obstacles and trials we often face.

The enemy loves it when we’re full of anxiety, miserable, and defeated because it mocks God, whose image we bear. But the “glory of God is man fully alive,” Saint Ireneaus.

What Satan wants for us

  • John 10:10 – To kill, steal, and destroy.
  • 1 Peter 5:8 – Satan hunts and wants to devour you.
  • 1 Samuel 18:10 – Harmful spirit rushed to King Saul to kill David.
  • John 10:20 – The man has a demon and is insane.
  • Luke 22:31–32 – He wants to sift God’s workers like wheat

What God wants for us

  • John 10:10 – Have life to the fullest and live it abundantly.
  • James 4:7 – Resist the devil so that it will flee.
  • Matthew 17:14-18 – Rebuked the enemy in Jesus’ name.
  • Luke 6:18 – Seek Jesus to heal our troubled minds caused by impure spirits.
  • John 15:5 – To bear fruit and be victorious by abiding in Christ.

Whatever the root cause of depression is, Jesus is our savior!

Thankfully, we have Jesus as our protector, redeemer, and friend. God equipped us to overcome anxiety, but we must exercise faith to focus on the good and trust God. Share your burdens through counseling.

Galatians 6:2
Share each other’s burdens, and obey the law of Christ.

Focus on what is good and trust God.

[1] NCBI – Religious and Spiritual Factors in Depression.
[2] APA – How Religious Beliefs Can Protect Psychological Well-being.
[3] Miller, Fletcher, Kabat-Zinn – Mindfulness meditation.
[4] NCBI – Neural correlates of healing prayers, depression, and traumatic memories.
[5] Wiley, Todd Chan – Religious beliefs compensate for purpose in life in the socially disconnected.


Bible verses for anxiety depressive disorder.
How to overcome depression Biblically.

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